Antibacterial and Antifungal Activity of Synthesized Potassium Dithiocarbazinates: A Preliminary In Vitro Study

Authors

  • Ali Shahryari M.Sc. Student, Department of Biology, Faculty of Science, University of Zabol, Zabol, Iran
  • Hamid Beyzaei Associate Professor, Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran
Abstract:

Background:The spread of drug-resistant microbial strains has led many studies for identifying, designing, and synthesizing new antimicrobial agents.The aim of this study was to evaluate antimicrobial effects of some synthesized potassium dithiocarbazinate derivatives against 6 Gram-negative and 4 Gram-positive bacteria as well as 2 molds and 1 yeast. Potassium salts of dithiocarbazinic acids were prepared in good yields from the reaction of various hydrazides with carbon disulfide. Potassium hydroxide and diethyl ether were used as base and solvent, respectively. Methods:Broth microdilution and streak plate methodswere applied according to the Clinical and Laboratory Standards Institute (CLSI) guidelines to determine the minimum inhibitory concentration (MIC), the minimum bactericidal concentration (MBC), and the minimum fungicidal concentration (MFC) values. Results:Good to excellent inhibitory effects especially on fungi were observed with the tested compounds. Dithiocarbazinates 3b and 3f containing 4-nitrophenyl and 3-hydroxy-2-naphthyl substituents could effectively inhibit the growth of all tested bacterial strains. In addition, all synthesized derivatives were effective against fungal pathogens. Conclusion:Based on the data obtained from antimicrobial susceptibility testing,designed derivatives are especially potent antifungal agents. Potassium 2-(3-hydroxy-2-naphthoyl) hydrazine-1-carbodithioate was introduced as a new wide-spectrum antimicrobial agent. Other biological activities of these water-soluble derivatives can be studied in living organisms.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Antimicrobial and Antioxidant Activity of the Biologically Synthesized Tellurium Nanorods; A Preliminary In vitro Study

Background: Recent theranostic (therapeutic or diagnostic) applications of tellurium nanoparticles have attracted a great interest for development of different methods for synthesis of this valuable nanostructure, especially via biological resources. Objectives: In the present study, the antimicrobial and antioxidant effects of the tellurium nanorods (Te NRs) biosynthesized by a bacterial...

full text

In Vitro Antibacterial and Antifungal Activity of Salicylanilide Benzoates

The resistance to antimicrobial agents brings a need of novel antimicrobial agents. We have synthesized and found the in vitro antibacterial activity of salicylanilide esters with benzoic acid (2-(phenylcarbamoyl)phenyl benzoates) in micromolar range. They were evaluated in vitro for the activity against eight fungal and eight bacterial species. All derivatives showed a significant antibacteria...

full text

a contrastive study of rhetorical functions of citation in iranian and international elt scopus journals

writing an academic article requires the researchers to provide support for their works by learning how to cite the works of others. various studies regarding the analysis of citation in m.a theses have been done, while little work has been done on comparison of citations among elt scopus journal articles, and so the dearth of research in this area demands for further investigation into citatio...

effects of first language on second language writing-a preliminary contrastive rhetoric study of farsi and english

to explore the idea the investingation proposed, aimed at finding whether the performances of the population of iranians students studying english in an efl context are consistent in l1 and l2 writing taks and whether there is a cross-linguistic transfer in this respect. in this regard the subjects were instructed to write four compositions-two in english and two in farsi-which consisted of an ...

15 صفحه اول

Study on the antioxidant activity and in vitro antifungal activity of Verbascum speciosum methanolic extract

The present study was conducted to determine the antioxidant and antifungal effects ofmethanol extract from aerial part of Verbascum speciosum. The total phenolic andflavonoid content and the antioxidant activity of the plant extract were determined byusing the Folin-Ciocalteau and the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free radicalscavenging assays. The total phenols and flavonoid content o...

full text

The Antibacterial Activity of Aloe vera: An in-vitro study

Abstract Introduction: The aim of this study was to identify the antibacterial components in the ethanol extraction of Aloe vera against four clinically frequent pathogenic  bacteria. Materials and Methods: In this in-vitro study, Aloe vera extraction was prepared by dissolving 500 grams of the powder in 5L of 95% ethanol. The antibacterial activity of the extraction against Staphylococcus a...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 27  issue 5

pages  394- 403

publication date 2020-09-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023